The 10 Best Boutique Hotels with Spa in Northern Aegean Islands (2025)

Nestled in the azure embrace of the Aegean Sea, the Northern Aegean Islands are a treasure trove of stunning landscapes, charming villages, and rich cultural heritage. From the sun-kissed shores of Lesvos to the lush hills of Chios, this idyllic region captivates visitors with its old-world architecture, tantalizing cuisine, and warm local hospitality. Here, boutique hotels play an essential role in enhancing the travel experience, offering personalized service and unique design that reflect the islands' vibrant spirit. For instance, the Eressian Hotel & Hammam Spa invites guests to unwind in luxurious surroundings while indulging in wellness treatments inspired by ancient traditions. Meanwhile, Galazio Asteri combines eco-friendly luxury with breathtaking views, perfectly aligning with the area's natural beauty. Toxotis Villas offers a private retreat where guests can immerse themselves in authentic island life, all while enjoying modern comforts. Explore our collection of Northern Aegean Islands boutique hotels with spa services and embark on a journey to discover the charm and tranquility of this enchanting paradise.

List Of Best Boutique Hotels with Spa Northern Aegean Islands

boutique hotels in Northern Aegean Islands

Eressian Hotel & Hammam Spa

Hotel
Eressian Hotel & Hammam Spa, Eresos, 81105, Greece

Nestled in the serene embrace of Eresós, the Eressian Hotel & Hammam Spa is a luxurious haven where modern comforts meet timeless Greek charm. Each corner whispers tales of relaxation and rejuvenation, inviting you into an intimate escape adorned with soothing aromas and gentle Mediterranean breezes.

Spa Retreat - Immerse yourself in pure tranquility at our exquisite Hammam Spa, where the air is infused with calming essential oils and the sound of trickling water lulls you into blissful relaxation. Indulge in tailored massage therapies that melt away tension, leaving you refreshed and renewed.

Culinary Delights - Awaken your senses each morning with a sumptuous breakfast featuring local delicacies, from fresh-baked pastries to robust coffees. The inviting aroma of Marsha's signature dishes wafts through the air, promising a delightful start to your day amidst the stunning backdrop of Eresós.

Charming Accommodations - Experience the essence of Greek hospitality in our beautifully designed rooms, each echoing the elegance of a classical Greek home. Textured linens and artisanal decor create a cozy ambiance, complemented by private balconies showcasing breathtaking sea views or tranquil village life.

Guest Experiences - As you settle into your room, the calming scent of lavender drifts from the nearby hills, while the laughter of friendly staff fills the air, making you feel right at home. Revel in the warm embrace of this boutique refuge, where even the softest sounds of nature weave into your most relaxing stay.

boutique hotels in Northern Aegean Islands

Galazio Asteri 1 Green, Luxury & Eco

Apartment
Paralia Thermis, Loutrópolis Thermís, 81100, Greece

Nestled along the sun-kissed shores of Loutrópolis Thermís, Galazio Asteri 1 Green, Luxury & Eco unveils an enchanting sanctuary where luxury harmoniously intertwines with nature. With an infinity pool that seemingly pours into the azure sea and a warm familial embrace from attentive hosts, this eco-friendly retreat invites you to indulge in both relaxation and adventure amid stunning coastal views.

Eco-Conscious Luxury - Experience a sustainable getaway where elegance meets environmental mindfulness. Each thoughtfully designed apartment features state-of-the-art amenities, inviting you to unwind in style while connecting with nature's beauty just outside your window.

Spa & Wellness Retreat - Soothe your senses at the on-site spa and wellness center, where tranquil sounds and soothing aromas create an oasis of relaxation. Whether enjoying a rejuvenating treatment or basking by the outdoor fireplace under twinkling stars, serenity is always within reach.

Family-Friendly Amenities - With a dedicated children's playground and a kids' pool filled with laughter, families can create joyful memories together. Enjoy leisurely afternoons exploring the local charm, then return to your spacious suite equipped for self-catering, perfect for family bonding time.

Guest Experiences - Each morning, guests are greeted with the citrusy sweetness of fresh mandarins plucked from the owners' own garden, filling the air with a delightful fragrance. The warmth of hospitality is palpable as hosts like Michaela and Dimitri treat every visitor as part of their extended family, ensuring your stay is as memorable as it is cozy.

boutique hotels in Northern Aegean Islands

Toxotis Villas

Apartment
Armenistis, Armenistis, 83301, Greece

Nestled within the sun-kissed hills of Armenistis, Toxotis Villas offers a sanctuary of tranquility and elegance, where every moment feels like a stolen escape. The enchanting gardens sway softly in the gentle Aegean breeze, while the infinity pool mirrors the azure sky, inviting you to unwind and indulge in luxurious leisure amidst breathtaking sea views.

Romantic Getaways - Perfect for couples seeking intimacy, the villas' private balconies and plush hot tubs create an idyllic setting for sunset soirees and starry-eyed evenings, where romance flourishes against the stunning backdrop of Ikaria's coastline.

Spa and Wellness Retreat - Delve into rejuvenation with specialized wellness packages that include serene yoga classes and blissful spa treatments, all designed to harmonize your mind and body as you bask in the soothing sounds of nature surrounding you.

Chic Beach Life - Just a leisurely stroll from the pristine shores of Armenistis Beach, embrace the laid-back luxury of beachside living, complete with vibrant local markets and quaint seaside tavernas that beckon with the aroma of fresh seafood and Mediterranean delights.

Guest Experiences - As guests sipped their morning coffee by the pool, the scent of blooming jasmine wafted through the air, evoking a sense of paradise. One visitor recalled how the kindness of the staff transformed their stay; a warm smile from Alexandra felt like an embrace, making them feel not just welcomed, but truly at home.

boutique hotels in Northern Aegean Islands

Varos Village Boutique Hotel

Hotel
Main Street, Varos, 81401, Greece

Nestled in the charming village of Varos, Greece, Varos Village Boutique Hotel offers an exquisite blend of modern elegance and tranquil seclusion. With every corner adorned with thoughtful design and a serene atmosphere that whispers luxury, this boutique oasis invites couples, wellness seekers, and cultural explorers to unwind and indulge in a truly romantic escape.

Chic Accommodations - Each room radiates sophistication with carefully curated decor, plush furnishings, and a unique touch that feels like a personal retreat. Enjoy the gentle breeze on your private balcony while sipping freshly brewed coffee, or luxuriate in the soothing ambiance enhanced by high-quality amenities.

Gastronomic Delights - Savor the flavors of Greece at the hotel's restaurant, where homemade pastries and fresh local ingredients create a delightful breakfast experience in a stunning setting. The warm aroma of baked goods mingles with the morning sea air as you plan your adventures over delicious fare.

Serene Retreat - The seasonal outdoor swimming pool beckons for leisurely afternoons, surrounded by lush gardens that invite tranquility. Take a pause under the sun's golden rays, perhaps indulging in a rejuvenating soak in the hot tub while listening to the soft rustle of leaves overhead.

Guest Experiences - Upon arrival, guests are greeted not just by staff but by heartfelt hospitality; Ioanna’s radiant smile makes you feel right at home, as if you've stepped into a cherished friend's abode. As you settle into your beautifully quiet room, the only sounds are the distant waves and the comforting hum of a well-appointed space, inviting restful nights.

boutique hotels in Northern Aegean Islands

Casa Cook Samos - Adults only

Hotel
Potokaki Pythagorion, Pythagoreio, 83103, Greece

Nestled along the sun-kissed shores of Pythagoreio, Casa Cook Samos invites you to indulge in an oasis of tranquility and elegance, exclusively for adults. With its chic design harmonizing with lush gardens and sweeping sea views, this luxurious retreat offers a romantic getaway where every moment feels like a cherished memory.

Spa and Relaxation - Immerse yourself in bliss at our Turkish bath, where aromatic essences waft through steam-filled air, creating a serene escape perfect for rejuvenation. Here, tranquility envelops you as you surrender to soothing treatments that leave your mind and body recharged.

Outstanding Location - A mere stroll from Potokaki Beach, the hotel’s prime location offers easy access to soft sands and crystal waters, making impromptu beach days effortless. Picture yourself wandering the shoreline, the gentle lapping of waves serenading your every step.

Chic and Intimate Design - Each room is a sanctuary of style, featuring modern furnishings and subtle textures that entice the senses. Guests have relished the calming ambiance complemented by thoughtful details—a cozy coffee station here, a private balcony overlooking the sea there—perfect for unwinding after a day of exploration.

Guest Experiences - Guests rave about the unforgettable breakfast, where the aroma of freshly baked pastries mingles with the scent of rich coffee, creating a morning ritual that sets the tone for the day. One visitor fondly recalled the quietude of their room, enhanced by the soft rustle of leaves outside, inviting a peaceful nap amidst the vibrant gardens.

boutique hotels in Northern Aegean Islands

Doryssa Theorem Hotel

Hotel
Πυθαγόρειο Σάμος, Pythagoreio, 83103, Greece

Nestled in the enchanting seaside town of Pythagoreio, Doryssa Theorem Hotel invites you to discover a sanctuary where modern luxury intertwines with rich history. An adults-only haven, this elegant retreat offers intimate spaces adorned with contemporary decor that beckon couples and solo travelers alike, promising both romance and rejuvenation amid stunning Aegean vistas.

Romantic Break - With a serene garden and an inviting terrace, each corner of Doryssa Theorem Hotel whispers romance, creating perfect settings for quiet moments or candlelit dinners under the stars.

Spa Breaks - Indulge in the hotel's sophisticated spa, where soothing aromas envelop you, and expert hands work wonders, ensuring your well-being is prioritized from the moment you step through the door.

Outstanding Location - Centrally located, the hotel is just a short stroll from the picturesque port, vibrant markets, and alluring beaches, making it an ideal base for both cultural explorers and adventure seekers.

Guest Experiences - As you sip on a complimentary welcome drink upon arrival, the staff's warm hospitality sets the tone for your stay; guests have remarked on the delightful surprise of fresh pastries wafting through the lobby each morning, enticing them to savor the exquisite breakfast spread.

boutique hotels in Northern Aegean Islands

Samian Mare Hotel, Suites & Spa

Hotel
KANARI 123, Karlovasi, 83200, Greece

Nestled along the pristine shores of Samian Mare Beach in Karlovasi, the Samian Mare Hotel, Suites & Spa exudes an inviting elegance that beckons both relaxation and adventure. With its chic modern design, lush surroundings, and a staff dedicated to treating you like family, every moment spent here feels like a cherished getaway.

Total Relaxation - Indulge your senses at the tranquil spa, where the scent of soothing essential oils mingles with soft, calming music, transporting you to a realm of serenity. From rejuvenating massages to holistic wellness treatments, each experience is tailored to envelop you in pure bliss.

Foodies - Savor delectable American, Greek, and Mediterranean delights at the on-site restaurant, where flavors come alive against stunning views. Picture starting your morning with freshly brewed coffee as the sun kisses the sea, followed by a breakfast spread that tempts even the most discerning palates.

Romantic Break - Embrace romance in rooms adorned with chic decor and private balconies offering breathtaking mountain views. The soft rustling of the leaves outside complements intimate evenings spent enjoying a glass of local wine as the twilight sky weaves a tapestry of colors.

Guest Experiences - A guest shared how they were welcomed with warm smiles and personalized notes that made them feel special from the very first moment. They reminisced about the delightful surprise of a birthday celebration orchestrated by the attentive staff, complete with a delicious cake that filled the air with sweet anticipation.

boutique hotels in Northern Aegean Islands

Doryssa Boutique Hotel

Hotel
- -, Pythagoreio, 83103, Greece

Nestled in the charming coastal town of Pythagoreio, Doryssa Boutique Hotel invites you to indulge in a sanctuary of elegance and tranquility. Here, every moment is infused with the enchanting scent of blooming Mediterranean flowers, and the turquoise whispers of nearby waves create an atmosphere that feels both luxurious and intimately personal.

Romantic Break - Doryssa offers an idyllic escape for couples seeking intimacy amidst breathtaking surroundings, where each room is designed as a serene haven—complete with subtle hues, plush textures, and delightful city views that stretch beyond the horizon.

Spa breaks - Immerse yourself in rejuvenation at our spa, where soothing aromas mingle with soft melodies to transport you away from the world, allowing you to rediscover bliss through tailored treatments that pamper body and soul.

Boutique - With its chic design elements and curated local artworks adorning the walls, the hotel encapsulates a unique blend of modern sophistication and traditional charm, inviting guests to feel as though they’ve stumbled into a stylish friend’s home rather than a standard hotel.

Guest Experiences - Upon arriving, guests are often greeted with refreshing coolness from the air conditioning, but it’s the unexpected little touches—a complimentary bottle of prosecco chilled just right or the private pool area that seems almost too good to be true—that leave lasting impressions, turning ordinary stays into unforgettable memories.

boutique hotels in Northern Aegean Islands

Erato by Samian Mare

Hotel
115, KANARI STR, Karlovasi, 83200, Greece

Nestled in the charming coastal town of Karlovasi, Erato by Samian Mare offers a luxurious sanctuary where elegance meets modern comfort. As you wander through the lush gardens and breathe in the salty air from nearby Samian Mare Beach just minutes away, prepare to be enveloped in a serene atmosphere, perfect for romantic getaways or rejuvenating escapes.

Total Relaxation - Unwind in the seasonal outdoor swimming pool, where the gentle lapping of water mingles with the soft whispers of palm leaves swaying in the breeze, creating an oasis of tranquility right at your doorstep.

Culinary Delights - Savor a delightful fusion of American, Greek, and Japanese cuisine at the hotel's exquisite restaurant, where the aroma of freshly prepared dishes intermingles with the sound of laughter from guests enjoying breakfast on the sun-drenched terrace.

Bicycle Adventures - Embrace the spirit of adventure and explore the stunning landscapes of Samos with convenient bicycle rentals, allowing you to traverse picturesque trails lined with vibrant wildflowers and breathtaking vistas that stir the soul.

Guest Experiences - Guests have marveled at the enchanting atmosphere created by the friendly staff, whose warm welcome and helpful recommendations transformed every moment into something special—like discovering the perfect hidden beach while basking in the golden sunset glow.

boutique hotels in Northern Aegean Islands

Theofilos Paradise Boutique Hotel

Hotel
Skra 7, Mytilene, 81100, Greece

Nestled in the heart of Mytilini, Theofilos Paradise Boutique Hotel is a haven of tranquility and elegance, where the whispers of history blend seamlessly with modern luxury. Just a short stroll from the sun-kissed shores of Tsamakia Beach, this enchanting hotel invites you to indulge in its serene atmosphere, characterized by exquisite design and personal touches that make each moment feel special.

Romantic Retreat - With its intimate ambiance and luxurious rooms featuring hydromassage showers, Theofilos Paradise provides the perfect backdrop for couples seeking a romantic getaway. Picture yourself basking under the stars at the rooftop pool, cocktail in hand, as you savor the gentle sea breeze and the glow of the surrounding city lights.

Culinary Delights - Start your day with an authentic Greek breakfast served in a chic dining room, where fragrant coffee mingles with the aroma of fresh pastries. Guests have raved about the charming staff who go the extra mile, such as personally brewing traditional Greek coffee, ensuring each breakfast feels like a warm embrace.

Historic Charm - Housed in a lovingly restored mansion dating back to 1912, Theofilos Paradise tells a story of timeless elegance and heritage. The reception hall, adorned with classic marble and vintage details, enchants visitors, making them feel as if they’ve stepped into a beautifully curated gallery that speaks to the island's rich past.

Guest Experiences - As guests unwind in the inviting lounge, the crackling sound of the fireplace fills the air, complementing the comforting scent of freshly brewed coffee. One traveler fondly recalled the delight of closing their balcony doors to silence the lively sounds of the nearby bar, creating a peaceful retreat without sacrificing convenience.

Best Boutique Hotels with Spa that guests love in Northern Aegean Islands

boutique hotels in Northern Aegean Islands
Skra 7, Mytilene, 81100, Greece
9.0
520 reviews
From $155

Guest Review: Attitude of the staff towards us was so kind. They were so polite. They tried to do what we wished.

boutique hotels in Northern Aegean Islands
Potokaki Pythagorion, Pythagoreio, 83103, Greece
9.4
502 reviews
From $218

Guest Review: Great Hotel with a perfect location and so cool interior design. Gonna come back again for sure.

boutique hotels in Northern Aegean Islands
Πυθαγόρειο Σάμος, Pythagoreio, 83103, Greece
9.3
454 reviews
From $174

Guest Review: I stayed 5 nights in the suite with a terrace. The room was clean and very comfortable. Staff and breakfast were outstanding and the Spa was a very nice bonus. Very near to all the nice places in Pythagorio but the room and hotel were in a quiet area.. The bed and bathroom are of a very high quality. A nice bottle of white wine was highly appreciated.

Northern Aegean Islands Boutique Hotels on the Map

Frequently Asked Questions

For a luxurious spa experience, consider staying at Eressian Hotel & Hammam Spa, known for its exquisite wellness offerings, or Samian Mare Hotel, Suites & Spa, which combines modern design with indulgent spa treatments. Both provide a serene atmosphere perfect for relaxation.

Food lovers will delight in Galazio Asteri 1 Green, Luxury & Eco, where fresh local ingredients create culinary masterpieces, and Doryssa Theorem Hotel, offering a unique blend of traditional flavors and modern gastronomy. These hotels promise a memorable dining experience amidst stunning settings.

For a romantic getaway, check out Casa Cook Samos - Adults only, boasting chic interiors and a tranquil vibe, or Doryssa Boutique Hotel, which offers beautiful views and intimate spaces perfect for couples. Both hotels create an enchanting atmosphere for lovebirds.

Travelers seeking value should explore Varos Village Boutique Hotel, where comfort meets affordability, and Erato by Samian Mare, known for its cozy ambiance without breaking the bank. Both provide excellent service and amenities at competitive prices.

For breathtaking views, stay at Toxotis Villas, featuring panoramic vistas of the Aegean Sea, or Theofilos Paradise Boutique Hotel, which offers scenic landscapes and stylish accommodations. Enjoy the beauty of the islands from your hotel room!

Families will enjoy their stay at Doryssa Theorem Hotel, which provides spacious rooms and child-friendly amenities, or Samian Mare Hotel, Suites & Spa, perfect for families seeking relaxation and fun activities. Both hotels cater to all ages ensuring a delightful family vacation.