The 6 Best Boutique Hotels with Spa in Mesaria (2025)

Nestled in the heart of Mesariá, Noūs Santorini is a luxurious oasis that embodies the essence of contemporary elegance and tranquil retreat. With its breathtaking views and sumptuous surroundings, this five-star resort invites couples, wellness enthusiasts, and travelers seeking solitude to indulge in moments of blissful serenity away from the bustling world.

Romantic Escape - Each thoughtfully designed room at Noūs Santorini offers a private sanctuary where soft linens and delicate textures create an inviting atmosphere, perfect for unwinding after a day of island explorations or reveling in peaceful intimacy.

Total Relaxation - The serene ambiance of the spa beckons guests to unwind; from the subtle scent of lavender wafting through the air to the gentle, soothing sounds of water features, every moment spent here is dedicated to rejuvenation and tranquility.

Outstanding Location - Conveniently situated near iconic landmarks and local markets, Noūs Santorini serves as your gateway to discovering the rich history and vibrant culture of Santorini, all while providing a quiet retreat to return to after a day filled with adventure.

Guest Experiences - Amidst the laughter at breakfast, the aroma of fresh coffee mingles with pastries, creating a warm and inviting start to the day. Guests often find themselves lost in conversation on sun loungers, sharing stories under the gentle warmth of the sun, highlighting the intimate connections formed within this elegant setting.

Nestled in the tranquil embrace of Mesariá, Altera Pars Suites offers a sanctuary of refined elegance and intimate luxury. Each suite, thoughtfully adorned with a blend of modern sophistication and local charm, invites romance and relaxation, boasting private plunge pools that shimmer under the Santorini sun, enticing you to unwind in absolute privacy.

Private Oasis - Step into your unique suite, where the allure of a personal plunge pool or hot tub awaits, inviting you to indulge in serene moments while gazing at the picturesque landscape surrounding you.

Culinary Delights - Savor the first light of day as the aroma of freshly brewed coffee mingles with warm croissants, delivered right to your suite, creating an inviting atmosphere that transforms breakfast into a cherished ritual.

Exploration Made Easy - With its enviable location just a stone's throw from vibrant attractions, Altera Pars Suites serves as the perfect launchpad for adventure seekers wishing to explore the rich history and breathtaking sights of Santorini.

Guest Experiences - Imagine waking to the sound of birds chirping outside your terrace, where a friendly host surprises you with local dining tips and ensures your morning feast is perfectly tailored to your tastes, each bite bursting with flavors that transport you deeper into Greek culture.

Nestled on the enchanting cliffs of Fira, De Sol Hotel & Spa invites you to immerse yourself in a world of elegance and tranquility. With stunning views stretching across the shimmering Aegean Sea, each moment here feels like a private retreat, where luxury harmonizes with nature's beauty, making it the perfect hideaway for lovers and seekers of serenity alike.

Romantic Escape - Intimate terraces adorned with fragrant bougainvillea create an idyllic backdrop for sunset cocktails, while whispering breezes carry the sweet scent of the sea, ensuring every evening flows into an intimate and unforgettable experience.

Total Relaxation - Indulge your senses at our upscale spa, where the soothing sounds of soft melodies blend with aromatic oils, transporting you to a realm of peace and rejuvenation — an oasis for wellness enthusiasts seeking solace from the outside world.

Outstanding Location - Just a leisurely stroll away from the heart of Fira Town, guests can wander through charming alleys lined with local artisan shops and vibrant markets, all while relishing breathtaking vistas that showcase Santorini's iconic sunsets.

Guest Experiences - Imagine waking up to the gentle rustle of leaves and stepping onto your private balcony, where the sun spills golden light over the horizon. Guests have delighted in the friendly staff who go out of their way, packing warm pastries for early departures, leaving them with the taste of home-baked goodness as they embark on new adventures.

Nestled gracefully along the breathtaking caldera of Fira, Nautilus Dome Suites offers an enchanting escape where luxury meets tranquility. Here, the soothing whispers of the Aegean breeze mingle with the warm glow of sunset views, creating a romantic backdrop perfect for couples and wellness enthusiasts alike. Each moment spent in this boutique haven is imbued with the essence of Santorini's beauty, inviting guests to savor every detail.

Romantic Retreat - Each suite features a private balcony or patio that looks out onto the mesmerizing landscape, transforming ordinary moments into extraordinary experiences as you sip morning coffee surrounded by serene vistas.

Local Exploring - With taverns and bars just a short stroll away, immerse yourself in the vibrant local culture—where fresh seafood dishes and traditional flavors await your discovery amidst charming streets.

Total Relaxation - Unwind by the inviting pool, which glimmers under the sun’s embrace, providing a perfect spot to bask in serenity while enjoying refreshing drinks crafted at the pool bar, making for an idyllic afternoon escape.

Guest Experiences - One guest recounted their delight as the enticing aroma of fresh pastries from the nearby bakery wafted through the air, perfectly punctuating lazy breakfast mornings spent on their terrace, each bite accompanied by sweeping views of the iconic caldera.

Perched on the dramatic caldera cliffs of Fira, Volcano View by Caldera Collection offers an enchanting escape where luxury meets breathtaking vistas. With sunsets that ignite the Aegean Sea in hues of orange and pink, this haven invites you to immerse yourself in a world of elegance, romance, and tranquility, enhanced by the warm embrace of Greek hospitality.

Romantic Break - Whisk your loved one away to a serene atmosphere filled with picturesque views and intimate dining experiences, all while enjoying the gentle sound of waves lapping against the cliffs below.

Outstanding Location - Nestled just beyond the bustling center of Fira, the hotel provides the perfect balance of seclusion and accessibility, allowing you to wander through charming streets or return to your private terrace to savor unobstructed views of the iconic Caldera.

Spa breaks - Rejuvenate your body and soul within the hotel's luxurious surroundings, complemented by refreshing dips in one of three pools overlooking the volcano, where sun-kissed skin meets the fresh scent of sea air.

Guest Experiences - As dawn breaks, the aroma of freshly brewed Greek coffee fills the air, drawing guests to the restaurant for breakfast. One traveler recalls how they were welcomed at the crack of dawn, their enthusiasm met with a smile as staff rushed to accommodate their early arrival, making them feel cherished from the very start.

Nestled on the precipice of Santorini's breathtaking caldera, Celestia Grand invites you into a world where luxury intertwines with the stunning tapestry of the Aegean Sea. Each villa, a private sanctuary adorned with elegant simplicity, boasts its own pool and hot tub, allowing couples and wanderers alike to soak in the mesmerizing sunsets that paint the skies above the volcanic landscape.

Total Relaxation - Indulge in blissful serenity as you unwind in your private hot tub, surrounded by panoramic views that can only be rivaled by the enchanting sunsets of Santorini. The soothing sounds of water gently lapping against the cliffside create a tranquil soundtrack for your luxurious escape.

Romantic Break - Experience love anew in this idyllic retreat, where sun-drenched mornings begin with breakfast served on your terrace and evenings are spent enveloped in each other’s company under a star-studded sky. Each moment feels crafted just for you, from champagne toasts in the hot tub to intimate dinners overlooking the caldera.

5* Luxury - Every detail at Celestia Grand whispers elegance and comfort, from the plush furnishings to the impeccable service provided by Niko and his attentive team. Guests revel in personalized recommendations for exploring the island, each tailored experience ensuring that your stay is as unforgettable as the setting itself.

Guest Experiences - Upon arrival, the rich aroma of freshly brewed coffee mingled with the salty sea breeze greeted guests, instantly easing them into vacation mode. Niko's thoughtful gesture of having the hot tub warmed and ready created a cozy haven, where they could surrender to the night, sipping drinks while the vibrant hues of sunset danced across the horizon.