The 10 Best Boutique Hotels with Spa in Panama City (2025)

Nestled in the heart of Panama City's financial district, Bristol Panama, a Registry Collection Hotel, invites you to experience a sanctuary of elegance and tranquility. This luxurious retreat boasts meticulously designed spaces that whisper sophistication, perfect for couples seeking romance or business travelers craving convenience amidst the vibrant pulse of the city.

Total Relaxation - Indulge in the serene ambiance of our spa center, where the soothing aroma of essential oils fills the air as expert therapists deliver rejuvenating massages tailored to your needs. Afterward, unwind in the sauna, enveloped in warmth and tranquility.

Culinary Delights - Savor the exquisite flavors of gourmet Panamanian cuisine at our on-site restaurant, where every bite is a journey through local heritage. The temptation of innovative tapas at the lounge bar creates an inviting atmosphere, perfect for leisurely evenings filled with laughter and delightful conversations.

Outstanding Location - Step outside to discover Uruguay Street, just footsteps away, brimming with tantalizing restaurants, lively bars, and cultural experiences waiting to be explored. The proximity adds a layer of excitement to your stay, making each moment feel effortlessly vibrant.

Guest Experiences - Guests have raved about the warm, inviting lobby filled with soft chatter and the subtle scent of freshly brewed coffee wafting through the air, perfectly complimented by the welcoming smiles of the staff. One mentioned a particularly delightful breakfast buffet where the deliciously fluffy pastries seemed to melt in their mouth, making mornings feel like a special occasion.

Nestled in the vibrant heart of Panama City, the Renaissance Panama City Hotel invites you to experience a seamless blend of contemporary elegance and local charm. With its chic design and lush tropical courtyard, every corner whispers a promise of relaxation and indulgence, perfect for couples seeking romance or business travelers yearning for a serene escape.

Outstanding Location - Just moments away from the iconic Panama Canal and the historic Casco Antiguo, this hotel serves as your gateway to an adventure steeped in culture and breathtaking sights. Feel the pulse of the city as you explore bustling local markets and savor the vibrant atmosphere.

Spa Breaks - Unwind in the holistically designed spaces of our spa, where soothing aromas fill the air and skilled therapists cater to your every need. Immerse yourself in a world of tranquility, making it the ideal sanctuary for wellness enthusiasts and those looking to recharge after a day of exploration.

Lively Area - Surrounded by the lively buzz of Avenida Via Espana, you'll find an array of dining and entertainment options just steps away, yet within the hotel, peace finds you again in the inviting embrace of our garden courtyard. It’s a place where urban energy meets serene reprieve, catering to both adventure seekers and relaxation lovers alike.

Guest Experiences - Guests often reminisce about the delightful surprise of anniversary gifts left in their rooms, a thoughtful touch reflecting the warm hospitality that resonates throughout the hotel. The aroma of freshly brewed coffee mingling with the scent of tropical blooms creates a comforting ambiance, while the laughter and chatter from the bar hint at memorable evenings spent sharing stories over expertly crafted cocktails.

Nestled along the shimmering shores of Panama Bay, JW Marriott Panama is an oasis of elegance where luxury entwines with unparalleled views. The air is infused with the scent of salt and blooming tropical flowers, creating an inviting atmosphere perfect for romance or rejuvenation as you soak in the beauty that surrounds you.

Spectacular Views - Every room boasts a private balcony, allowing you to bask in breathtaking vistas of the Panamanian Bay—where sunrises paint the sky in hues of pink and gold, setting the perfect backdrop for your morning coffee.

Lush Infinity Pool - The remarkable infinity pool seems to blend seamlessly with the ocean, offering a tranquil haven where laughter mingles with the gentle sound of waves lapping against the shore, inviting you to unwind in its refreshing embrace.

Culinary Journeys - Embark on a gastronomic adventure with our diverse selection of onsite restaurants and bars, where each dish is a celebration of flavors curated by our Executive Chef, and every bite tells a story of local ingredients and culinary artistry.

Guest Experiences - As you lounge by the infinity pool, the warm sun kisses your skin while the delightful aroma of freshly made avocado toast wafts through the air—a guest recalls how the attentive staff's genuine smiles made the experience feel like a cherished day spent among friends.

Nestled in the heart of Panama City, where the vibrant pulse of the business district meets serene luxury, Waldorf Astoria Panama offers an oasis of sophistication and charm. This elegant retreat beckons with its modern design infused with warm hospitality, ensuring that each moment spent here feels like a cherished escape into indulgence.

Culinary Delights - Savor culinary artistry at Matiz, where global flavors dance upon your palate, and the terrace invites you to bask in breathtaking city views as the sun sets. Alternatively, unwind at The Peacock Alley, where expertly crafted cocktails and light bites create the perfect backdrop for intimate conversations.

Spa & Relaxation - Rejuvenate your senses in our luxurious spa, where calming aromas envelop you, and skilled hands work magic to melt away tension. The tranquil ambiance invites wellness enthusiasts to indulge in bespoke treatments designed to restore balance and serenity.

Outstanding Location - Just steps from Balboa Avenue’s picturesque waterfront, guests can explore scenic walking paths along the Pacific Ocean, immersing themselves in the vibrant local culture while enjoying proximity to fabulous dining and entertainment options hidden within charming side streets.

Guest Experiences - Guests often remark on the enchanting moments, like the delightful aroma of fresh pastries wafting through the air during breakfast, paired with the gentle sound of soft jazz from the lobby. One guest was particularly touched when the staff surprised them with a personalized birthday cake, transforming an ordinary day into an unforgettable celebration.

Nestled between the lush embrace of a vibrant rainforest and the sparkling allure of Playa Bonita Beach, The Westin Playa Bonita Panama is an oasis of tranquility that whispers romance and luxury. Here, every sunrise casts golden hues over the Pacific Ocean, setting the perfect backdrop for couples seeking an intimate escape or adventure seekers ready to explore the enchanting beauty of Panama.

Romantic Getaway - With its breathtaking ocean views and serene ambiance, this upscale retreat invites you to unwind in intimate luxury, whether lounging by the infinity pool or sipping cocktails at sunset on the private beach.

Spa & Relaxation - Surrender to bliss at the sensory spa, where soothing scents of tropical botanicals infuse the air, and each treatment promises to rejuvenate both body and soul amidst an atmosphere of calm.

Culinary Delights - Savor the diverse culinary landscape with six unique dining venues, from Pan-Asian delicacies to Mediterranean delights, where every bite tells a story crafted from fresh, local ingredients that tantalize the palate.

Guest Experiences - As guests stroll through the gardens, they often remark on the delightful fragrance of hibiscus mingling with sea salt in the air, while friendly staff members offer recommendations for nearby excursions, including a memorable drive over the canal that sparks joy and adventure.

Nestled on the sun-kissed shores of Isla Taboga, the Taboga Palace SPA Hotel invites you to indulge in a world where luxury meets tropical serenity. With the gentle sound of waves lapping at the shore and breathtaking ocean views from your private balcony, every moment here feels like a cherished escape—a romantic hideaway designed for lovers, adventurers, and those seeking rejuvenation amid nature’s beauty.

Spa Retreat - Elevate your senses in our luxurious spa, where aromatic oils and soothing sounds create an oasis of tranquility. Here, indulgent treatments await to refresh your spirit amidst stunning island vistas.

Infinity Pool with a View - Take a dip in our inviting infinity pool that seemingly merges with the horizon, providing a perfect backdrop for relaxing afternoons. As the sun sets, watch the sky transform into a canvas of colors while sipping a cocktail crafted by our attentive staff.

Culinary Delights - Savor the flavors of local Panamanian cuisine just steps from your room. Enjoy meals at nearby restaurants with picturesque decks overlooking the beach, where fresh catches mingle with the salty sea breeze, creating a feast for both the palate and the soul.

Guest Experiences - Awakening to the scent of fresh coffee, one guest relished their mornings spent on the balcony, basking in the warm sunlight while taking in panoramic views of the glistening waters. The engaging stories shared by owner Dave over refreshing margaritas added a personal touch, making each encounter feel like a joyful rendezvous with a friend.

Nestled on the enchanting shores of Taboga Island, Villa Caprichosa Boutique Hotels invites you into a world where luxurious charm intertwines with the serene sounds of the ocean. Each suite, artfully curated by the renowned Diane Burn, boasts breathtaking vistas and an intimate atmosphere that whispers romance and tranquility, making it a perfect escape for lovers and wellness seekers alike.

Romantic Retreat - Indulge in a haven of intimacy as you stroll hand-in-hand along the secluded beaches, feeling the warm sand underfoot while the sun dips below the horizon, painting the sky in hues of orange and pink—a perfect backdrop for cherished moments.

Spa & Relaxation - Unwind in our serene spa, where the soothing scent of essential oils fills the air, and skilled therapists melt away your tension, leaving you refreshed and rejuvenated amid the island's tranquil embrace.

Chic Accommodations - Experience the elegant design of our spacious suites, where plush textiles meet vibrant artworks, creating a sanctuary that feels both lavish and inviting, all while offering panoramic views of ships awaiting their passage through the famed Panama Canal.

Guest Experiences - One guest delightedly recalled sipping coffee on their private balcony, the aroma mingling with the salty breeze, while admiring the stunning décor and soaking in the peaceful surroundings—each detail subtly enhancing their unforgettable stay.

Nestled amidst the vibrant greenery of Cacique, Ciel y Miel beckons travelers with its enchanting blend of luxury and nature. Here, breathtaking views of the Caribbean Sea unite with every intimate detail to create a serene sanctuary, perfect for romance or relaxation—your personal slice of paradise awaits.

Spa & Relaxation - Indulge in holistic rejuvenation at our exceptional spa, where soothing aromas and gentle sounds create an oasis of tranquility, allowing you to unwind in style while surrounded by the lush Panamanian landscape.

Beach Life - Step onto your private beach, where the soft, warm sand meets clear turquoise waters; it's a perfect spot for sunbathing or losing yourself in the gentle rhythm of the waves, creating lasting memories under the Caribbean sun.

Boutique - Experience upscale boutique charm as each corner reveals unique elements—handcrafted decor, stunning artworks, and attentive service that make every moment feel curated just for you, ensuring a stay that’s anything but ordinary.

Guest Experiences - As you wander the grounds, the laughter of monkeys echoes through the trees, while the scent of fresh seafood wafts from the restaurant, enticing you to indulge in a delightful dinner served on crisp white tablecloths, all beneath a sky filled with stars.

Nestled within the lush embrace of Valle de Anton, Casa Madre Tierra offers a sanctuary where elegance meets nature's tranquility. The air is infused with the sweet scent of tropical flowers, while the soft rustle of palm leaves creates a soothing backdrop for those seeking romance and relaxation in this enchanting hideaway.

Total relaxation - Step into a world of serenity as you unwind by the shimmering outdoor pool, surrounded by vibrant gardens that invite quiet contemplation and leisurely strolls. Here, every moment feels like a gentle embrace from nature itself.

Romantic Break - Intimate dining awaits at the on-site restaurant, where candlelight dances over expertly crafted dishes that celebrate local flavors, igniting sparks of romance with every bite. Share laughter and stories beneath a starlit sky, enveloped in the warmth of each other's company.

Wellbeing - Embrace holistic wellness in thoughtfully designed spaces throughout the hotel, from peaceful lounges adorned with local artworks to serene nooks perfect for yoga or a good book. Bask in the sense of community while enjoying bespoke spa treatments that rejuvenate both body and spirit.

Guest Experiences - As the sun dipped below the horizon, guests often found themselves enchanted by the fragrance of fresh herbs wafting from the kitchen, a precursor to the gourmet delights that awaited them. It was not uncommon to hear laughter echoing from the cozy lounge, where new friendships blossomed over complimentary cocktails curated by the attentive staff.

Nestled in the serene embrace of Valle de Anton, Caracoral Hotel Boutique offers a chic getaway where luxury meets nature. As you wander through the vibrant gardens, the air is fragrant with tropical blooms, setting the perfect stage for romantic evenings under twinkling stars and tranquil mornings by the sparkling pool.

Romantic Retreat - With intimate nooks and cozy patios, this boutique hotel inspires connection, whether it's over a candlelit dinner featuring American cuisine or during leisurely afternoons beside the pool, serenaded by the gentle rustle of palm leaves.

Local Explorations - Step outside to discover the lush landscapes of Valle de Anton, where cycling paths weave through breathtaking scenery, inviting guests to immerse themselves in the region's natural beauty and vibrant local culture.

Spa & Relaxation - Unwind from your adventures with restorative treatments designed to rejuvenate body and spirit, complemented by the soothing ambiance of the hotel’s tranquil garden—a true haven for wellness enthusiasts.

Guest Experiences - One guest recalled the delightful surprise of finding a ping pong table on the balcony, where laughter echoed beneath the setting sun, while another cherished the friendly staff who made every meal feel like a home-cooked feast, leaving behind the comforting scent of spices and fresh ingredients.