The 16 Best Boutique Hotels in Santa Fe De Antioquia (2025)

Nestled in the enchanting heart of Santa Fe de Antioquia, Casa Bixa Hotel Boutique offers a sanctuary of tranquility and luxury exclusively for adults. Here, every corner whispers romance, every detail invites relaxation, and the outside world fades away as you immerse yourself in an oasis designed for the discerning traveler.

Total Relaxation - The outdoor swimming pool beckons with its crystalline waters, framed by lush gardens, where soothing sounds of nature harmonize with gentle breezes, creating an inviting escape from the everyday hustle.

Romantic Hideaway - With intimate lighting and chic decor that exudes modern elegance, each room serves as a personal retreat, providing a serene atmosphere for couples seeking privacy and a touch of luxury amidst vibrant surroundings.

Culinary Delights - Savor a delightful à la carte breakfast that awakens your senses—freshly brewed coffee wafting through the air, paired with an array of local delicacies that tantalize the taste buds, setting the perfect tone for the day ahead.

Guest Experiences - One guest recounted the delight of waking to the fragrant aroma of breakfast, mingling with the morning sun filtering through their elegantly decorated room, while the attentive staff, always ready with a warm smile, made them feel like cherished friends rather than just visitors.

Nestled in the enchanting hills of Santa Fe de Antioquia, Hotel Boutique Al Alma offers a serene escape where elegance meets intimacy. With its romantic courtyard adorned with lush greenery and twinkling lights, this boutique retreat invites couples and travelers alike to indulge in luxurious tranquility while enjoying breathtaking views of the stunning Colombian landscape.

Romantic Break - Each beautifully appointed room exudes chic sophistication, featuring plush textures and inviting atmospheres that set the perfect stage for intimate evenings. Imagine sipping wine on your private balcony, listening to the gentle rustle of leaves and distant laughter from the pool area.

Spa Breaks - Immerse yourself in rejuvenating bliss at the hotel's spa, where the air is infused with calming scents of essential oils, promising a sanctuary for wellness enthusiasts seeking relaxation and renewal amid nature’s embrace.

Local Exploring - Step outside and wander the vibrant streets of Santa Fe de Antioquia, where colonial architecture and colorful markets beckon cultural explorers. The charming local shops and rich history add a dash of adventure to your stay, allowing you to savor authentic Colombian experiences.

Guest Experiences - One guest recounted the delightful surprise of finding a hidden nook by the pool, where the aroma of fresh jasmine mingled with the sound of trickling water, creating an idyllic escape for quiet moments. Another noted the warmth of the staff, who went out of their way to arrange a candlelit dinner under the stars, turning an ordinary evening into a cherished memory.

Nestled within the historic heart of Santa Fe de Antioquia, Hotel Mariscal Robledo is a sanctuary where colonial charm meets modern elegance. Surrounded by lush tropical gardens, this exquisite retreat invites couples and wellness seekers to unwind in its tranquil embrace, offering a haven for those yearning for romance, relaxation, and a touch of adventure.

Romantic Retreat - Embrace the allure of intimacy as you stroll hand-in-hand beneath the fragrant jasmine that adorns the property, or savor a candlelit dinner on the terrace with breathtaking views of the surrounding mountains—a perfect backdrop for unforgettable memories.

Spa & Relaxation - Indulge your senses at our serene spa, a peaceful oasis where soothing melodies and the scent of essential oils drift through the air, promising rejuvenation through blissful massages that melt away stress and invite tranquility.

Historic Elegance - Step into a world where time slows down; the hotel's character beams from every corner, with beamed ceilings and carefully curated artworks echoing stories of the past, making you feel as though you've been transported into a charming Colombian postcard.

Guest Experiences - Wander into cozy nooks filled with antiques and art, where the faint rustle of palm leaves harmonizes with the gentle sounds of laughter floating from the bar poolside. Guests speak of the warmth in the air and how they lost track of time while lounging by the inviting pool, basking in the sun and sipping on locally inspired cocktails.

Tucked away in the vibrant heart of Santa Fe de Antioquia, Selva María Hotel Boutique invites you into a world where modern chic meets historic charm. Here, each corner whispers tales of romance as lush greenery envelops your senses, providing an intimate escape that feels both exclusive and welcoming.

Romantic Retreat - Indulge in the ambiance of love within our elegantly designed spaces, where soft lighting and tasteful artworks create perfect settings for whispered secrets and shared laughter.

Wellness Oasis - Unwind in our soothing hot tub or explore local markets brimming with vibrant colors and scents, all while enjoying leisurely moments that rejuvenate body and soul.

Cultural Explorer's Haven - Discover the treasures of this historic town just moments from your doorstep, with cobblestone streets leading you to captivating sights, bustling cafes, and cultural experiences waiting to unfold.

Guest Experiences - As you step into the hotel, the delicate aromas of freshly brewed coffee greet you, mingling with the laughter of friendly staff who treat you like family, turning every interaction into a delightful moment to remember.

Nestled in the heart of Santa Fe de Antioquia, Ángel de Santa Fe by Bernalo Hotels invites you to indulge in a serene escape where traditional charm meets modern comforts. As you step through the lush gardens, the gentle rustle of palms and the sweet scent of blooming flowers immediately envelop you, setting the stage for an unforgettable retreat characterized by intimacy and warmth.

Romantic Break - Couples can bask in the enchanting ambiance of the terrace, where twilight paints the sky in hues of amber and lavender, providing a perfect backdrop for intimate dinners under the stars.

Spa breaks - Unwind your senses in the indoor pool's crystal-clear waters, paired with rejuvenating wellness offerings that promise tranquility and relaxation amidst the rustic beauty of the Colombian landscape.

Local exploring - Venture into the vibrant streets nearby, where the rich tapestry of local markets and historic sites awaits—each corner revealing Colombia's culture and warm-hearted community.

Guest Experiences - Many guests have shared delightful moments spent lounging by the pool, where the laughter of children harmonizes with the distant sounds of live music from the bar, creating a lively yet soothing atmosphere that feels like a cherished family gathering.

Nestled in the enchanting embrace of Santa Fe de Antioquia, Hotel Boutique Los Gentiles is a hidden gem where modern elegance meets serene relaxation. The inviting gardens and shimmering outdoor pool create an oasis of tranquility, ideal for couples seeking romance or solo travelers yearning for rejuvenation amidst nature’s beauty.

Romantic Retreat - Every corner of this boutique hotel whispers intimacy—from the soft glow of sunset filtering through lush greenery to the luxurious private balconies that offer breathtaking views. Perfectly crafted for honeymooners and romantic getaways, each moment feels like a cherished secret shared between lovers.

Total Relaxation - Experience bliss as you unwind in the bubbling hot tub under a starlit sky, surrounded by the gentle sounds of nature. The outdoor spaces beckon with the allure of lazy afternoons spent lounging by the pool, where time seems to stand still, allowing complete escape from the everyday hustle.

Cultural Explorers - Immerse yourself in the rich local culture as the vibrant streets of Santa Fe come alive just beyond your doorstep. With convenience in mind, leisurely strolls lead you to nearby markets brimming with artisan crafts and culinary delights, promising an authentic taste of Colombian life.

Guest Experiences - One evening, as twilight painted the horizon, the aroma of freshly prepared local dishes wafted through the air, enticing guests to gather in the charming restaurant. It was here that laughter mingled with the soft strumming of a guitar, creating an ambiance so warm and inviting that it felt like a cherished gathering among friends.

Nestled in the vibrant heart of Medellín, Hotel Colores Boutique invites you to experience a harmonious blend of modern luxury and Colombian charm. The air is infused with the essence of local flora as you step into this chic oasis, where every detail has been meticulously curated to ensure privacy, comfort, and an unforgettable stay amidst the city's lively rhythm.

Romantic Retreat - Escape to a haven designed for intimacy, where soft lighting and tasteful decor create a serene ambiance perfect for couples and honeymooners seeking cherished moments together.

Total Relaxation - Unwind in the inviting outdoor swimming pool or soak under the stars in the hot tub, enveloped by the soothing sounds of nature, offering a true sanctuary from the bustle of everyday life.

Outstanding Location - Just a stone's throw from the city's cultural gems and nightlife, Hotel Colores Boutique positions you perfectly to explore the rich tapestry of Medellín while providing a tranquil base to return to.

Guest Experiences - Imagine sipping fresh coffee on your private terrace, the aroma mingling with the scent of blooming flowers in the garden. Guests have noted how the attentive staff greeted them with warm smiles, sharing local tips that turned their afternoons into delightful adventures, filled with unexpected discoveries.

Nestled within the vibrant energy of Medellín, DUO BOUTIQUE HOTEL offers a serene adult-only retreat designed for intimate escapes and unique adventures. With its lush garden and chic terrace, the ambiance is infused with warmth and tranquility—an ideal backdrop for romantic getaways or rejuvenating wellness journeys.

Romantic Break - Every corner of DUO exudes romance, from candlelit evenings under the stars on the terrace to the subtle scent of blooming flowers wafting through the air, inviting couples to unwind and reconnect.

Spa Breaks - Indulge in total relaxation at the hotel’s spa, where every treatment is a carefully curated experience designed to awaken your senses, enveloping you in calming aromas and soothing sounds that whisk you away from the everyday hustle.

Outstanding Location - Positioned in a tranquil neighborhood, the hotel places you moments away from local gems, allowing you to explore charming cafés and vibrant markets while returning each evening to a peaceful sanctuary away from the city buzz.

Guest Experiences - One guest recalled the delightful surprise of enjoying breakfast as the sun filtered through the trees, while another found solace in the simple pleasure of sipping coffee on the terrace, accompanied by the soft rustle of leaves and chirping birds.

Nestled in the vibrant Laureles district of Medellín, Hotel Boutique Laureles Medellin (HBL) invites you to indulge in a chic escape where modern elegance meets authentic Colombian warmth. With its serene garden and stylish terrace, this boutique haven offers an intimate atmosphere perfect for couples and discerning travelers alike, merging luxury with the heartbeat of the city.

Romantic Retreat - Experience romance in every corner, from cozy rooms adorned with plush linens to quiet nooks that beckon for whispered conversations over a glass of Colombian wine on the terrace, surrounded by fragrant blooms and a soft breeze.

Culinary Delights - Awaken your senses with a sumptuous breakfast featuring local delicacies and freshly brewed coffee, served in a sunlit dining area where the aroma of pastries mingles with laughter and the clinking of cutlery, creating a joyful start to your day.

Chic Local Exploration - Step outside into the lively streets lined with trendy cafes and boutique shops, just moments away from the hotel; the vibrant energy of the neighborhood pulses around you, inviting spontaneous discoveries and delightful encounters at every turn.

Guest Experiences - As one guest remarked, the air was filled with the gentle hum of laughter while enjoying breakfast, paired with the comforting scent of freshly baked bread that made them feel right at home, all within a stone's throw from inviting bars and eateries.

Nestled in the vibrant heart of Medellín's Laureles - Estadio district, Hotel Boutique Laureles Home - Ayenda 1258 offers a harmonious blend of modern chic and intimate charm. Guests are enveloped in an inviting atmosphere where the allure of contemporary design meets the warmth of Colombian hospitality, creating a sanctuary for romantic getaways, cultural explorations, or leisurely retreats.

Outstanding Location - Conveniently positioned just a stone's throw from Laureles Park, this boutique hotel invites you to stroll through tree-lined streets, savoring the city's local culture and culinary delights at nearby cafés and markets.

Romantic Break - With cozy, elegantly appointed rooms often kissed by the soft glow of morning light, couples can find solace on private balconies, sipping coffee while soaking up Medellín's enchanting ambiance, perfect for unwinding together.

Total Relaxation - Designed for tranquility, the hotel's shared lounge becomes a peaceful retreat, where the aroma of freshly brewed coffee mingles with gentle laughter, allowing guests to connect, read, or simply unwind in a serene setting.

Guest Experiences - One guest recalled the delightful surprise of waking up to the gentle sounds of chirping birds outside their window, complemented by a comforting scent of fresh pastries wafting from the kitchen, making each day feel like a special occasion.

Nestled in the vibrant heart of Medellín, Factory Lofts Hotel invites you to experience a symphony of modern luxury and urban charm. With its chic loft-style accommodations and lush rooftop pool, this sanctuary is an oasis where romance, relaxation, and cultural exploration intertwine seamlessly.

Romantic Retreat - Indulge in intimate moments as you unwind in spacious rooms adorned with contemporary art and plush furnishings, offering stunning city views that set the perfect backdrop for cherished memories.

Culinary Delights - Awaken your senses each morning with a carefully curated continental or American breakfast, featuring local flavors that tantalize your palate while you sip fresh Colombian coffee amid a warm, inviting atmosphere.

Wellness Haven - Refresh your spirit in the hotel's serene outdoor swimming pool, where gentle breezes mingle with the scent of blooming flowers, creating a tranquil space perfect for sun-soaked afternoons or starlit evenings.

Guest Experiences - One guest marveled at the super-comfy bed, noting the soothing ambiance that enveloped the room, while another shared how Jimena, the staff member, went above and beyond, orchestrating a surprise gift that left their partner speechless amidst the hotel's welcoming embrace.

Nestled in the vibrant heart of Medellín, Hotel Boutique Plaza is a chic haven where modern elegance meets Colombian warmth. With its intimate atmosphere and stylish decor, it's the perfect retreat for those seeking a romantic escape or a serene space for unwinding after a day of exploration.

Outstanding Location - Positioned just steps away from local markets and iconic sights, guests can revel in the rich culture of Medellín without straying far from the hotel’s welcoming embrace. The bustling streets echo with laughter and chatter, creating a vibrant backdrop to your stay.

Total Relaxation - Each room is adorned with contemporary touches, offering a peaceful sanctuary to unwind. As you sink into plush linens surrounded by thoughtfully placed artworks, the gentle hum of the city outside fades away, inviting you to recharge in serenity.

Romantic Break - With soft ambient lighting and cozy spaces, the hotel curates an enchanting atmosphere for couples. Picture sipping coffee on a sunlit terrace, the aroma of freshly brewed beans mingling with the scent of blooming flowers, providing a perfect moment of connection.

Guest Experiences - As you step through the doors, the courteous staff greets you like an old friend, their friendly banter adding a personal touch that makes you feel settled right away. You may catch the faint sound of laughter from the shared lounge, where small groups of friends share stories over evenings filled with local delicacies.

Nestled in the vibrant Laureles - Estadio district, Rivière Boutique Hotel invites you to bask in luxury with an intimate atmosphere that feels both chic and utterly inviting. Each room is a serene retreat, adorned with local artwork and modern comforts, offering a perfect backdrop for romantic getaways or tranquil solo escapes.

City Style - Immerse yourself in Medellín's lively heartbeat, where each corner of the hotel embodies urban sophistication, and the bustling streets are just a leisurely stroll away, ripe for exploration.

Romantic Break - Craft unforgettable memories with your loved one as you unwind in elegantly designed spaces, share intimate dinners featuring locally-sourced cuisine, and enjoy quiet moments amidst the enchanting ambiance.

Spa breaks - Indulge in rejuvenating spa services, where soothing scents fill the air and the expert hands of therapists work their magic, leaving you refreshed and ready to embrace the city's adventures.

Guest Experiences - Imagine waking up to the gentle sounds of the city coming alive outside your window while the rich aroma of freshly brewed coffee wafts through the hallways, reminding you that this delicate blend of energy and tranquility is what makes Rivière feel like home.

Nestled in the vibrant heart of Medellín, The Somos Bold Hotel invites you to indulge in a blend of chic modernity and local charm. With its lush gardens and stylish design, the atmosphere is both intimate and exhilarating, offering couples and adventurers alike an inviting retreat just moments away from the city's lively pulse.

Total Relaxation - Unwind in luxurious spaces, where each room is thoughtfully curated with elegant decor, plush furnishings, and private terraces that beckon for sunset cocktails overlooking the cityscape.

Romantic Break - Experience romance in the air as you enjoy exquisite breakfast spreads featuring freshly made omelets and tropical fruits, perfect for savoring while basking in the sunlight filtering through the vibrant greenery.

City Style - Immerse yourself in the chic urban vibe of Medellín, with the hotel’s rooftop bar becoming your go-to spot for live music and crafted cocktails, all amidst stunning views of the surrounding hills and city lights.

Guest Experiences - A guest recalls the delight of discovering the cozy rooftop bar, where the scent of fresh coffee mingles with soft melodies, making it impossible to resist lingering a little longer. They marveled at how attentive staff like Gabriela turned simple requests into heartfelt gestures, truly enhancing their experience.

Nestled in the vibrant heart of Medellín, Vita Hotel Boutique offers an intimate escape where chic design meets modern comforts. The soothing scent of fresh coffee wafts through the air as you step into the elegantly adorned lobby, drawing you into a world where every detail is meticulously curated to enhance your experience.

Outstanding Location - Just a leisurely stroll from El Poblado Park and Lleras Park, embrace the perfect setting for local exploration, with a blend of culture, cuisine, and nightlife right at your doorstep.

Total Relaxation - Retreat into your air-conditioned sanctuary, where plush bedding and the tranquil ambiance promise restful nights, ensuring each day begins refreshed and ready for adventure in this captivating city.

Romantic Break - Ideal for couples seeking romance, the hotel’s charming terrace invites you to unwind under the stars, while the soft sounds of Medellín's evening rush hum gently in the background, creating a perfect backdrop for heartfelt conversations.

Guest Experiences - One guest recalled the delightful surprise of a breakfast buffet that smelled so inviting, it felt like a warm hug on a plate, complemented by the cheerful demeanor of the staff who seemed genuinely invested in making each visit special.

Nestled in the vibrant El Poblado district of Medellín, Manila Hotel Boutique invites you into a world where modern elegance meets charming intimacy. As you step through its doors, the chic décor and warm ambiance envelop you, offering a sanctuary perfect for couples, solo adventurers, and cultural explorers alike. With a prime location just a stroll away from lush parks and buzzing nightlife, this boutique haven is your gateway to both relaxation and adventure.

Outstanding Location - Experience the best of Medellín with the hotel’s enviable proximity to Parque Lleras and eclectic dining options. A leisurely walk unveils a tapestry of local culture, vibrant cafes, and serene green spaces, ensuring you're never far from the city's pulse.

Total Relaxation - Indulge in restful moments in beautifully designed rooms, featuring plush beds and spacious bathrooms that invite you to unwind. Some accommodations offer balconies framed by lush greenery, while others boast sunny terraces—ideal spots for savoring morning coffee or evening cocktails.

Chic Boutique Style - Every corner of Manila Hotel Boutique reflects a sophisticated aesthetic, from the stylish bar to the thoughtfully curated art displayed throughout the property. The inviting atmosphere feels both upscale and approachable, making each guest feel at home while surrounded by tasteful elegance.

Guest Experiences - Guests have found delight in the friendly smiles of the staff, with one describing how Diego's attentive service transformed their early check-in experience into a warm welcome. The air carries an aromatic blend of fresh coffee and blooming flowers, while laughter from nearby cafés spills into the streets, crafting a lively yet soothing backdrop.