The 7 Best Boutique Hotels in Departamento De Santa Cruz (2025)

Nestled in the vibrant heart of Santa Cruz de la Sierra, Alfonsina Hotel Boutique beckons discerning travelers with its blend of modern elegance and intimate charm. Here, each moment is an invitation to indulge in luxurious comfort, whether you are sipping a morning latte on your private balcony or basking by the glistening outdoor pool under the Bolivian sun.

City Style - Experience the dynamic pulse of Equipetrol, where artful décor meets urban sophistication, and every corner showcases thoughtful design that resonates with the local culture.

Total Relaxation - Unwind in the serene embrace of our lush outdoor spaces, where the gentle sound of water from the pool mingles with soothing melodies, creating a sanctuary for rejuvenation and tranquility.

Romantic Break - Alfonsina is the perfect backdrop for romance; share candlelit dinners at nearby restaurants or take leisurely strolls through charming streets, all while enveloped in a sense of privacy and intimacy.

Guest Experiences - Imagine waking up to the aroma of freshly brewed coffee wafting through your room, the inviting warmth of plush linens beneath you, as you step onto the balcony to catch glimpses of city life unfolding below—this is the true essence of a stay at Alfonsina.

Nestled in the enchanting landscapes of Samaipata, El Pueblito Hotel Boutique offers an intimate escape where time slows down and nature embraces you. With its charming cluster of uniquely themed casas surrounding a tranquil courtyard, this haven invites romance and relaxation, framed by panoramic views that whisper tales of Bolivian charm and heritage.

Chic Ambiance - Each of the twelve beautifully crafted cabins tells its own story, adorned with eclectic décor that reflects the vibrant local culture. The scent of fresh blossoms wafts through the air, creating a serene atmosphere perfect for couples seeking a romantic getaway.

Total Relaxation - Embrace tranquility by the sparkling outdoor pool, where the gentle rustle of leaves mingles with soft bird calls. Guests often find themselves lounging here, basking under the sun while gazing at the breathtaking hills that cradle this boutique retreat.

Culinary Delights - Start your day with a sumptuous buffet breakfast infused with local flavors—imagine fresh fruits, rich coffee, and fluffy scrambled eggs served in a warm, inviting setting that feels just like home. The process of choosing from such a delightful array is a sensory adventure unto itself.

Guest Experiences - One guest fondly recalled waking up to the melodious sounds of nature, followed by a leisurely swim in the pool surrounded by lush greenery, feeling as if they had stumbled into a fairytale. Others cherished the friendly interactions with staff, who offered personal touches that made their stay feel genuinely special.

Nestled in the heart of Santa Cruz de la Sierra, Cosmopolitano Hotel Boutique beckons with its intimate charm and sophisticated ambiance. Each corner of this haven radiates warmth and artistry, enveloping guests in a serene escape where contemporary elegance meets Bolivian history.

Artworks & Local Exploring - Vibrant artworks grace the walls of this chic boutique hotel, each piece narrating a tale of local culture. Just a short stroll away, immerse yourself in the rich tapestry of nearby museums, where the essence of Bolivia's artistic heritage comes alive.

Romantic Break - With its inviting patios bathed in natural light, this romantic retreat offers endless opportunities for whispered secrets and stolen glances. The soothing sound of water splashing from the outdoor pool creates a tranquil backdrop, perfect for couples seeking a serene getaway.

Total Relaxation - From leisurely mornings spent lounging by the pool to evenings indulging in culinary delights at the quaint cafe, every moment here is designed for unwinding. Experience true comfort in rooms equipped with plush bedding and thoughtful amenities that make you feel right at home.

Guest Experiences - Imagine waking to the aroma of freshly brewed coffee wafting through the air, complemented by a breakfast spread that exceeded expectations—complete with crispy bacon and fluffy gluten-free toast. Guests have cherished the attentive staff, particularly Valeria, who effortlessly navigated their requests while sharing delightful recommendations for nearby adventures.

Nestled in the enchanting hills of Samaipata, Hostel Serena offers a serene retreat where the gentle rustle of leaves harmonizes with breathtaking mountain vistas. Here, the charm of Bolivian hospitality meets a rustic elegance, inviting couples and adventurers alike to unwind in this intimate haven that feels like home.

Romantic Getaway - With cozy corners perfect for stolen moments, Hostel Serena provides a picturesque backdrop for couples, accented by the warm glow of sunset views over the lush valley and the sweet scent of blooming flowers in the garden.

Bountiful Breakfasts - Every morning, awaken your senses with a delightful spread featuring fresh, homemade breads, creamy peanut butter, and local jams, all served with the aroma of freshly brewed coffee wafting through the air, setting the stage for a day of exploration.

Adventure Awaits - Step from the doorstep into nature’s playground, where scenic hiking trails beckon and cycling routes wind through stunning landscapes, making every excursion an unforgettable journey into the heart of Bolivia's captivating wilderness.

Guest Experiences - One guest described the bliss of lounging in a hammock, swaying gently as they savored the quiet peace and expansive views, while another delighted in the friendly banter with Bert and Maria, who filled their mornings with laughter and the irresistible smell of warm pastries.

Nestled in the enchanting hills of Samaipata, YVY CASA HOTEL is a hidden gem where nature meets artistry. This boutique retreat, enveloped by lush gardens and vibrant local culture, invites you to unwind in its cozy, thoughtfully designed spaces that echo the rich heritage of Bolivia.

Total Relaxation - Immerse yourself in tranquility as you stroll through beautifully maintained grounds, indulging in the peaceful ambiance that surrounds you, perfect for wellness enthusiasts and adventure seekers alike.

Culinary Delights - Awaken your senses each morning with a sumptuous breakfast crafted from fresh garden produce, including homemade flatbreads and marinated vegetables, offering a delectable taste of local flavors that linger delightfully on the palate.

Artful Accommodations - Each room tells its own story, featuring unique designs that blend comfort and charm, with cozy beds and whimsical bathrooms that encourage relaxation while offering breathtaking views of the verdant landscape.

Guest Experiences - As you step into the sunlit common areas, the enticing aroma of freshly baked pita wafts through the air, accompanied by laughter and friendly chatter from the staff, who take pride in ensuring every moment feels like a warm embrace.

Nestled in the heart of San José de Chiquitos, Rústico & Hotel Boutique Las Churapas is a tranquil oasis where the essence of Bolivian culture mingles with modern luxury. Here, each moment is crafted to create an intimate getaway, enveloped by lush gardens and the gentle sounds of nature, making it a perfect escape for romantic travelers and wellness seekers alike.

Total relaxation - Unwind in our inviting outdoor swimming pool, surrounded by verdant greenery that whispers promises of tranquility. The soft rustling leaves and distant birdsong create a serene backdrop as you sip a refreshing cocktail from the bar, losing yourself in the moment.

Local exploring - Experience the vibrant charm of the local markets and cultural treasures just moments away. Feel the pulse of San José de Chiquitos as you stroll through its historic streets, discovering artisanal crafts and colorful murals that narrate the rich tapestry of this enchanting town.

Spa breaks - Indulge in holistic rejuvenation at our spa, where the scent of natural oils fills the air, and expert hands guide you through a journey of relaxation. Each treatment is designed to harmonize body and mind, leaving you feeling renewed and deeply connected to the serene surroundings.

Guest Experiences - One guest reminisced about the warm welcome they received from the staff, who offered fresh tropical fruit upon arrival, filling the air with sweet scents. They also fondly recalled how the sun-drenched patio invited them to linger longer over breakfast, where vibrant flowers seemed to dance in the gentle breeze.

Nestled in the vibrant heart of Santa Cruz de la Sierra, Hotel Senses Equipetrol invites you to indulge in a sanctuary of modern elegance and serene comfort. With its chic design and an atmosphere that whispers romance, every corner is a perfect backdrop for cherished moments, whether you're basking by the pool or unwinding in the embrace of your luxurious room.

Total Relaxation - Immerse yourself in tranquility at the outdoor swimming pool, where gentle breezes carry the scent of tropical flora, providing a refreshing escape from daily life—perfect for sun-drenched afternoons and intimate evening dips under the Bolivian stars.

City Style - Experience urban sophistication with a touch of local culture; just steps away, you'll find bustling markets and vibrant nightlife, all while enjoying the chic aesthetic and attentive service that make each stay feel uniquely tailored to you.

Spa Breaks - Rejuvenate your senses in a sanctuary dedicated to wellness, where soothing sounds blend with the aromatic notes of essential oils, creating an oasis for relaxation and revitalization—ideal for couples seeking a romantic retreat or solo travelers on a journey of self-care.

Guest Experiences - As I strolled through the lobby, the subtle aroma of freshly brewed coffee mingled with the soft strains of local music, instantly making me feel at home. A staff member noticed my curiosity about nearby attractions and eagerly shared hidden gems, transforming my brief visit into an adventure filled with unforgettable discoveries.